Identification of a Novel Two-Partner Secretion Locus in Moraxella catarrhalis

Identification of a novel two-partner secretion locus in Moraxella catarrhalis.

Although Moraxella catarrhalis continues to be a significant cause of disease in both children and adults, the steps involved in pathogenesis remain poorly understood. We have identified three open reading frames in the M. catarrhalis genome that encode homologues of the two-partner secretion system (TPS). The sequenced M. catarrhalis hemagglutinin-like locus of strain 7169 has a unique gene or...

Identification of a novel two-partner secretion locus in 5 Moraxella catarrhalis

Moraxella catarrhalis - a rediscovered pathogen

Original Article Moraxella catarrhalis lower respiratory tract infection Beta Lactamase and Pneumonia

Identification and characterization of a novel outer membrane protein (OMP J) of Moraxella catarrhalis that exists in two major forms.

Moraxella catarrhalis is a common commensal of the human respiratory tract that has been associated with a number of disease states, including acute otitis media in children and exacerbations of chronic obstructive pulmonary disease in adults. During studies to investigate the outer membrane proteins of this bacterium, two novel major proteins, of approximately 19 kDa and 16 kDa (named OMP J1 a...

Characterization of a novel porin protein from Moraxella catarrhalis and identification of an immunodominant surface loop.

Moraxella catarrhalis is a gram-negative bacterium that is mainly responsible for respiratory tract infections. In this study we report a novel outer membrane protein (OMP), designated M35, with a molecular mass of 36.1 kDa. This protein was structurally homologous to classic gram-negative porins, such as OMP C from Escherichia coli and OMP K36 from Klebsiella pneumoniae, with a predicted struc...